Anti-RING2 antibody
Specifications
| Product Cat#: | AB-06-3880 |
| Product type: | Primary antibody |
| Antigen: | RING2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1000); Immunohistochemistry (1:50-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JB38-41) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | BAP 1 antibody |
| BAP1 antibody | |
| DING antibody | |
| DinG protein antibody | |
| E3 ubiquitin protein ligase RING 2 antibody | |
| E3 ubiquitin protein ligase RING2 antibody | |
| E3 ubiquitin-protein ligase RING2 antibody | |
| HIP2 interacting protein 3 antibody | |
| HIP2-interacting protein 3 antibody | |
| HIPI 3 antibody | |
| HIPI3 antibody | |
| Huntingtin interacting protein 2 interacting protein 3 antibody | |
| Huntingtin-interacting protein 2-interacting protein 3 antibody | |
| OTTHUMP00000060668 antibody | |
| Polycomb M33 interacting protein Ring 1B antibody | |
| Polycomb M33 interacting protein Ring1B antibody | |
| Protein DinG antibody | |
| RING 1B antibody | |
| RING 2 antibody | |
| RING finger protein 1B antibody | |
| RING finger protein 2 antibody | |
| RING finger protein BAP 1 antibody | |
| RING finger protein BAP-1 antibody | |
| RING finger protein BAP1 antibody | |
| RING1b antibody | |
| RING2_HUMAN antibody | |
| RNF 2 antibody | |
| Rnf2 antibody |
Target information
E3 ubiquitin-protein ligase that mediates monoubiquitination of ‘Lys-119’ of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).
Provider
Erpantech Laboratory
