Anti-RBL2 antibody
Specifications
| Product Cat#: | AB-06-3832 |
| Product type: | Primary antibody |
| Antigen: | RBL2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (8A-8C) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | 130 kDa retinoblastoma associated protein antibody |
| FLJ26459 antibody | |
| p130 antibody | |
| PRB 2 antibody | |
| PRB2 antibody | |
| Rb 2 antibody | |
| Rb2 antibody | |
| RBL 2 antibody | |
| RBL2 antibody | |
| RBR 2 antibody | |
| RBR2 antibody | |
| Retinoblastoma like 2 antibody | |
| Retinoblastoma like protein 2 antibody | |
| Retinoblastoma related gene antibody |
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Target information
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 ‘Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Provider
Erpantech Laboratory
