Anti-RANTES antibody
Specifications
| Product Cat#: | AB-06-3820 |
| Product type: | Primary antibody |
| Antigen: | RANTES |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1000); Immunohistochemistry (1:50-1:200); Immunocytochemistry/Immunofluorescence (1:50-1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (JM03-45) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Beta chemokine RANTES antibody |
| Beta chemokine RANTES precursor antibody | |
| C C motif chemokine 5 antibody | |
| CCL 5 antibody | |
| CCL5 antibody | |
| CCL5_HUMAN antibody | |
| Chemokine (C C motif) ligand 5 antibody | |
| Chemokine CC Motif Ligand 5 antibody | |
| D17S136E antibody | |
| EoCP antibody | |
| Eosinophil chemotactic cytokine antibody | |
| MGC17164 antibody | |
| RANTES(4-68) antibody | |
| Regulated upon activation normally T expressed and presumably secreted antibody | |
| SCYA 5 antibody | |
| SCYA5 antibody | |
| SIS delta antibody | |
| SIS-delta antibody | |
| SISd antibody | |
| Small inducible cytokine A5 (RANTES) antibody | |
| Small inducible cytokine A5 antibody | |
| Small inducible cytokine subfamily A (Cys Cys) member 5 antibody | |
| Small-inducible cytokine A5 antibody | |
| T cell specific protein p288 antibody | |
| T cell specific RANTES protein antibody | |
| T cell-specific protein P228 antibody | |
| T-cell-specific protein RANTES antibody | |
| TCP 228 antibody |
Target information
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
Provider
Erpantech Laboratory
