Anti-RAB8 antibody
Specifications
| Product Cat#: | AB-06-3791 |
| Product type: | Primary antibody |
| Antigen: | RAB8 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG2b |
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (B11-G8) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | AA409338 antibody |
| MEL antibody | |
| Mel transforming oncogene (derived from cell line NK14) RAB8 homolog antibody | |
| Mel transforming oncogene (derived from cell line NK14) antibody | |
| Mel transforming oncogene (RAB8 homolog) antibody | |
| Mel transforming oncogene antibody | |
| MGC124948 antibody | |
| Oncogene c mel antibody | |
| Oncogene c-mel antibody | |
| RAB8 antibody | |
| RAB8A antibody | |
| RAB8A member RAS oncogene family antibody | |
| RAB8A_HUMAN antibody | |
| Ras associated protein RAB8 antibody | |
| Ras related protein Rab 8A antibody |
Target information
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). May be involved in ciliogenesis (PubMed:21844891, PubMed:30398148). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069).
Provider
Erpantech Laboratory
