Anti-PTPRC antibody
Specifications
| Product Cat#: | AB-06-3763 |
| Product type: | Primary antibody |
| Antigen: | PTPRC |
| Immunogen: | Purified recombinant fragment of human PTPRC expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:600-1:2000); Immunohistochemistry (1:80-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (C11-C10) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | B220 antibody |
| CD 45 antibody | |
| CD45 antibody | |
| CD45 antigen antibody | |
| CD45R antibody | |
| GP180 antibody | |
| L-CA antibody | |
| LCA antibody | |
| Leukocyte common antigen antibody | |
| LY5 antibody | |
| Lyt4 antibody | |
| Protein tyrosine phosphatase receptor type C antibody | |
| Protein tyrosine phosphatase, receptor type, c polypeptide antibody | |
| Ptprc antibody | |
| PTPRC_HUMAN antibody | |
| Receptor-type tyrosine-protein phosphatase C antibody | |
| T200 antibody | |
| T200 glycoprotein antibody | |
| T200 leukocyte common antigen antibody |
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Target information
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).By similarity2 Publications
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.1 Publication
Provider
Erpantech Laboratory
