Anti-PRPF8 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | PRPF8 |
| Immunogen: | Recombinant protein within 1–200 of human PRPF8. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:2000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:200); Flow Cytometry (1:40-1:100) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (JG57-38) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 220 kDa U5 snRNP specific protein antibody |
| 220 kDa U5 snRNP-specific protein antibody | |
| Apoptosis regulated protein 1 antibody | |
| Apoptosis regulated protein 2 antibody | |
| HPRP8 antibody | |
| p220 antibody | |
| Pre mRNA processing factor 8 antibody | |
| Pre mRNA-processing factor 8, S. cerevisiae, homolog of antibody | |
| Pre-mRNA-processing-splicing factor 8 antibody | |
| Precursor mRNA processing protein antibody | |
| PRP8 antibody | |
| PRP8 homolog antibody | |
| PRP8 pre mRNA processing factor 8 homolog antibody | |
| PRP8_HUMAN antibody | |
| PRPC8 antibody | |
| Prpf8 antibody | |
| Retinitis pigmentosa 13 (autosomal dominant) antibody | |
| RP13 antibody | |
| SNRNP220 antibody | |
| Splicing factor Prp8 antibody | |
| U5 snRNP specific protein antibody | |
| U5 snRNP specific protein (220 kD), ortholog of S. cerevisiae Prp8p |
Target information
Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5′ and the 3′ splice site.
Provider
Erpantech Laboratory
