Anti-Prion Protein (PrP) antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Prion Protein (PrP) |
| Immunogen: | Synthetic peptide within Human Prion Protein aa 200-249/253. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:5000); Immunohistochemistry-Paraffin (1:50-1:800); Immunocytochemistry/Immunofluorescence (1:50-1:200); Flow Cytometry (1:50-1:100) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (SC57-05) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Alternative prion protein; major prion protein antibody |
| AltPrP antibody | |
| ASCR antibody | |
| CD230 antibody | |
| CD230 antigen antibody | |
| CJD antibody | |
| GSS antibody | |
| KURU antibody | |
| Major prion protein antibody | |
| p27 30 antibody | |
| PRIO_HUMAN antibody | |
| Prion related protein antibody | |
| PRIP antibody | |
| PRNP antibody | |
| PrP antibody | |
| PrP27 30 antibody | |
| PrP27-30 antibody | |
| PrP33-35C antibody | |
| PrPC antibody | |
| PrPSc antibody | |
| Sinc antibody |
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Target information
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Provider
Erpantech Laboratory
