Anti-PP2C alpha antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | PP2C alpha |
| Immunogen: | Full length PP2Cα of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:200-1:1000); Immunoprecipitation:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
| Reactivity: | Mouse, Human |
| Clonality (clone number): | Monoclonal (3G1) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, Protein phosphatase IA |
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Target information
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Provider
Erpantech Laboratory