Anti-PODXL antibody
Specifications
| Product Cat#: | AB-06-3639 |
| Product type: | Primary antibody |
| Antigen: | PODXL |
| Immunogen: | KLH conjugated synthetic peptide derived from mouse PODXL 351-450/558 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Podocalyxin |
| PCLP | |
| PCLP1 | |
| Podocalyxin-Like Isoform 1 Precursor | |
| Podocalyxin Like Protein | |
| PODXL_MOUSE | |
| GCTM-2 Antigen | |
| Gp200 | |
| Podocalyxin-Like protein 1 | |
| PC | |
| PCLP-1 | |
| PCX |
Target information
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Provider
Erpantech Laboratory
