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Anti-PKN1 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-07-3496
Anti-PKN1 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-07-3496
Product type: Primary antibody
Antigen: PKN1
Immunogen: A synthetic peptide derived from human PKN1/PRK1. The exact amino-acid sequence is proprietary.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:2500); ELISA (1:20000)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration: 1 mg/ml
Purity: Antigen affinity chromatography
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Alternative names: DBK; MGC46204; PAK1; PKN; PKN-ALPHA; PKN1; PRK1; PRKCL1; Protein kinase C-like 1; Protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase N1; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; serine-threonine kinase N; Seri
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Target information

PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates ‘Ser-575’, ‘Ser-637’ and ‘Ser-669’ of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of ‘Thr-11’ of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 ‘Lys-9’ (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates ‘Thr-38’ of PPP1R14A, ‘Ser-159’, ‘Ser-163’ and ‘Ser-170’ of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

Provider

Erpantech Laboratory

download

MSDS-AB-07-3496.pdf (120 downloads )