Anti-PKM2 antibody (KO Validated)
Specifications
| Product Cat#: | AB-06-4831 |
| Product type: | Primary antibody |
| Antigen: | PKM2 |
| Immunogen: | Synthetic peptide within human PKM aa 380-450. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:250-1:2000); Flow Cytometry (1:25-1:100) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Non-conjugated |
| Alternative names: | CTHBP antibody |
| Cytosolic thyroid hormone-binding protein antibody | |
| KPYM_HUMAN antibody | |
| OIP-3 antibody | |
| Opa-interacting protein 3 antibody | |
| p58 antibody | |
| pkm antibody | |
| PKM1 antibody | |
| PKM2 antibody | |
| Pyruvate kinase 2/3 antibody | |
| Pyruvate kinase muscle isozyme antibody | |
| Pyruvate kinase PKM antibody | |
| THBP1 antibody | |
| Thyroid hormone-binding protein 1 antibody | |
| Tumor M2-PK antibody |
Target information
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723).
The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723).
The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723).
In addition to its role in glycolysis, also regulates transcription (PubMed:18191611, PubMed:21620138).
Stimulates POU5F1-mediated transcriptional activation (PubMed:18191611).
Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).
Also acts as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity).
Plays a general role in caspase independent cell death of tumor cells (PubMed:17308100).
Provider
Erpantech Laboratory
