Anti-PINK1 antibody
Specifications
| Product Cat#: | AB-06-3586 |
| Product type: | Primary antibody |
| Antigen: | PINK1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1000); Immunocytochemistry (1:50-1:200); Immunohistochemistry (1:100-1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5% BSA, 50% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | BRPK antibody |
| FLJ27236 antibody | |
| Mitochondrial antibody | |
| PARK 6 antibody | |
| PARK6 antibody | |
| Phosphatase and Tensin Homolog antibody | |
| PINK 1 antibody | |
| PINK1 antibody | |
| PINK1_HUMAN antibody | |
| Protein Kinase BRPK antibody | |
| PTEN Induced Putative Kinase 1 antibody | |
| PTEN Induced Putative Kinase Protein 1 antibody | |
| PTEN-Induced Putative Kinase Protein 1 antibody | |
| Serine/Threonine Kinase PINK1 Mitochondrial antibody | |
| Serine/Threonine Protein Kinase PINK1 Mitochondrial antibody | |
| Serine/Threonine-Protein Kinase PINK1 antibody |
Target information
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at ‘Ser-65’ of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).
Provider
Erpantech Laboratory
