Anti-PI3-Kinase p85 Subunit Alpha antibody
Specifications
| Product Cat#: | AB-06-3578 |
| Product type: | Primary antibody |
| Antigen: | Kinase p85 Subunit Alpha |
| Immunogen: | Recombinant protein within human PI3-kinase p85 subunit alpha aa 1-200 |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:1000-1:2000); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (L3-D6) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | GRB1 antibody |
| p85 Alpha antibody | |
| p85 antibody | |
| P85A_HUMAN antibody | |
| Phosphatidylinositol 3 Kinase Associated p 85 Alpha antibody | |
| Phosphatidylinositol 3 Kinase Regulatory 1 antibody | |
| Phosphatidylinositol 3 Kinase, Regulatory Subunit, Polypeptide 1 (p85 Alpha) antibody | |
| Phosphatidylinositol 3-Kinase 85 kDa Regulatory Subunit Alpha antibody | |
| Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha antibody | |
| Phosphoinositide 3 kinase, Regulatory Subunit 1 (Alpha) antibody | |
| PI3 Kinase p85 Subunit Alpha antibody | |
| PI3-Kinase Regulatory Subunit Alpha antibody | |
| PI3-Kinase Subunit p85-Alpha antibody | |
| PI3K antibody | |
| PI3K Regulatory Subunit Alpha antibody | |
| Pik3r1 antibody | |
| PtdIns 3 Kinase p85 Alpha antibody | |
| PtdIns-3-Kinase Regulatory Subunit Alpha antibody |
Target information
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Provider
Erpantech Laboratory
