Anti-PI3-Kinase p85 Subunit Alpha antibody
Specifications
| Product Cat#: | AB-06-3577 |
| Product type: | Primary antibody |
| Antigen: | PI3-Kinase p85 Subunit Alpha |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:1000-1:2000); Flow Cytometry (1:50-1:100); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (A3-D0) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | GRB1 antibody |
| p85 alpha antibody | |
| p85 antibody | |
| P85A_HUMAN antibody | |
| Phosphatidylinositol 3 Kinase Associated p 85 Alpha antibody | |
| Phosphatidylinositol 3 Kinase Regulatory 1 antibody | |
| Phosphatidylinositol 3 Kinase, Regulatory Subunit, Polypeptide 1 (p85 Alpha) antibody | |
| Phosphatidylinositol 3-Kinase 85 kDa Regulatory Subunit Alpha antibody | |
| Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha antibody | |
| Phosphoinositide 3 Kinase, Regulatory Subunit 1 (Alpha) antibody | |
| PI3 Kinase p85 Subunit Alpha antibody | |
| PI3-Kinase Regulatory subunit Alpha antibody | |
| PI3-Kinase Subunit p85-Alpha antibody | |
| PI3K antibody | |
| PI3K Regulatory Subunit Alpha antibody | |
| Pik3r1 antibody | |
| PtdIns 3 Kinase p85 Alpha antibody | |
| PtdIns-3-Kinase Regulatory Subunit Alpha antibody |
Target information
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.
Provider
Erpantech Laboratory
