Anti-PI 3 Kinase p110 Delta antibody
Specifications
| Product Cat#: | AB-06-3572 |
| Product type: | Primary antibody |
| Antigen: | PI 3 Kinase p110 Delta |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500); Immunohistochemistry (1:50-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JM83-24) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 5-Bisphosphate 3-Kinase 110 kDa Catalytic Subunit Delta antibody |
| 5-bisphosphate 3-Kinase Catalytic Subunit Delta Isoform antibody | |
| APDS antibody | |
| GRB1 antibody | |
| IMD14 antibody | |
| p110d antibody | |
| p110delta antibody | |
| p110dp85a antibody | |
| p85-ALPHA antibody | |
| Phosphatidylinositol 3 Kinase Catalytic Delta Polypeptide antibody | |
| Phosphatidylinositol 4 5 Bisphosphate 3 Kinase Catalytic Subunit Delta Isoform antibody | |
| Phosphatidylinositol 4,5 Bisphosphate 3 Kinase 110 kDa Catalytic Subunit Delta antibody | |
| Phosphatidylinositol 4,5 Bisphosphate 3 Kinase, Catalytic Subunit Delta antibody | |
| Phosphatidylinositol 45 Bisphosphate 3 Kinase Catalytic Subunit Delta Isoform antibody | |
| Phosphatidylinositol-4 antibody | |
| Phosphoinositide 3 Kinase B antibody | |
| Phosphoinositide 3 Kinase C antibody | |
| Phosphoinositide 3 Kinase Catalytic Delta Polypeptide antibody | |
| Phosphoinositide 3 Kinase, Catalytic, Delta Polypeptide Variant p37 Delta antibody | |
| PI3 Kinase p110 Subunit Delta antibody | |
| PI3-Kinase Subunit Delta antibody | |
| PI3K antibody | |
| PI3K-Delta antibody | |
| PI3K Delta antibody | |
| Pik3cd antibody | |
| PIK3R1 antibody | |
| PK3CD antibody |
Target information
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.
Provider
Erpantech Laboratory