Anti-Phospho-SMC1 (S957) antibody
Specifications
| Product Cat#: | AB-06-3557 |
| Product type: | Primary antibody |
| Antigen: | Phospho-SMC1 (S957) |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Ser957 of human SMC1 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (SC65-03) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CDLS2 antibody |
| DKFZp686L19178 antibody | |
| DXhXs423e antibody | |
| DXS423E antibody | |
| KIAA0178 antibody | |
| MGC138332 antibody | |
| OTTHUMP00000061876 antibody | |
| RP6 29D12.1 antibody | |
| SB1.8 antibody | |
| Segregation of mitotic chromosomes 1 antibody | |
| Segregation of mitotic chromosomes like 1 antibody | |
| SMC 1 antibody | |
| SMC protein 1B antibody | |
| SMC-1-beta antibody | |
| SMC-1B antibody | |
| SMC1 antibody | |
| SMC1A antibody | |
| SMC1alpha antibody | |
| SMC1alpha protein antibody | |
| SMC1B antibody | |
| SMC1B_HUMAN antibody | |
| SMC1BETA antibody | |
| SMC1beta protein antibody | |
| SMC1L1 antibody | |
| SMC1L2 antibody | |
| SMCB antibody | |
| Structural maintenance of chromosome 1 like 1 protein antibody | |
| Structural maintenance of chromosome 1 like 2 protein antibody | |
| Structural maintenance of chromosomes 1A antibody | |
| Structural maintenance of chromosomes 1B antibody | |
| Structural maintenance of chromosomes protein 1B antibody |
Target information
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Provider
Erpantech Laboratory
