Anti-Phospho-Smad3 (S423/S425) antibody
Specifications
| Product Cat#: | AB-06-3555 |
| Product type: | Primary antibody |
| Antigen: | Phospho-Smad3 (S423/S425) |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Ser423 and 425 of human Smad3 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000); Immunohistochemistry (1:50-1:200); Immunofluorescence; Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (ST0493) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DKFZP586N0721 antibody |
| DKFZp686J10186 antibody | |
| hMAD 3 antibody | |
| hMAD-3 antibody | |
| hSMAD3 antibody | |
| HSPC193 antibody | |
| HST17436 antibody | |
| JV15 2 antibody | |
| JV15-2 antibody | |
| JV152 antibody | |
| LDS1C antibody | |
| LDS3 antibody | |
| MAD (mothers against decapentaplegic Drosophila) homolog 3 antibody | |
| MAD homolog 3 antibody | |
| Mad homolog JV15 2 antibody | |
| Mad protein homolog antibody | |
| MAD, mothers against decapentaplegic homolog 3 antibody | |
| Mad3 antibody | |
| MADH 3 antibody | |
| MADH3 antibody | |
| MGC60396 antibody | |
| Mothers against decapentaplegic homolog 3 antibody | |
| Mothers against DPP homolog 3 antibody | |
| SMA and MAD related protein 3 antibody | |
| SMAD 3 antibody | |
| SMAD antibody | |
| SMAD family member 3 antibody | |
| SMAD, mothers against DPP homolog 3 antibody | |
| Smad3 antibody | |
| SMAD3_HUMAN antibody |
Target information
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Provider
Erpantech Laboratory
