Anti-Phospho-SIRT1 (S47) antibody
Specifications
| Product Cat#: | AB-06-3551 |
| Product type: | Primary antibody |
| Antigen: | Phospho-SIRT1 (S47) |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Ser47 of human SIRT1 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:100-1:500) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (SN06-40) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 75SirT1 antibody |
| hSIR2 antibody | |
| hSIRT1 antibody | |
| HST2, S. cerevisiae, homolog of antibody | |
| NAD dependent deacetylase sirtuin 1 antibody | |
| NAD dependent protein deacetylase sirtuin 1 antibody | |
| OTTHUMP00000198111 antibody | |
| OTTHUMP00000198112 antibody | |
| Regulatory protein SIR2 homolog 1 antibody | |
| SIR1_HUMAN antibody | |
| SIR2 antibody | |
| SIR2 like 1 antibody | |
| SIR2 like protein 1 antibody | |
| SIR2, S.cerevisiae, homolog-like 1 antibody | |
| SIR2-like protein 1 antibody | |
| SIR2ALPHA antibody | |
| SIR2L1 antibody | |
| Sirt1 antibody | |
| SirtT1 75 kDa fragment antibody | |
| Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) antibody | |
| Sirtuin 1 antibody |
Target information
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:15152190, PubMed:14980222, PubMed:14976264). Serves as a sensor of the cytosolic ratio of NAD+/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5′-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871).
Provider
Erpantech Laboratory
