Anti-Phospho-SHIP (Y1020) antibody
Specifications
| Product Cat#: | AB-06-3549 |
| Product type: | Primary antibody |
| Antigen: | Phospho-SHIP (Y1020) |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Tyr1020 of human SHIP |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000); Immunoprecipitation; Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JJ082-03) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Inositol polyphosphate 5 phosphatase of 145kDa antibody |
| 4 antibody | |
| 5-trisphosphate 5-phosphatase 1 antibody | |
| hp51CN antibody | |
| Inositol polyphosphate 5 phosphatase 145kDa antibody | |
| Inositol polyphosphate 5 phosphatase antibody | |
| Inositol polyphosphate-5-phosphatase of 145 kDa antibody | |
| INPP5D antibody | |
| MGC104855 antibody | |
| MGC142140 antibody | |
| MGC142142 antibody | |
| p150Ship antibody | |
| Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody | |
| Phosphatidylinositol-3 antibody | |
| SH2 containing inositol phosphatase isoform b antibody | |
| SH2 domain containing inositol 5' phosphatase 1 antibody | |
| SH2 domain containing inositol phosphatase 1 antibody | |
| SH2 domain-containing inositol phosphatase 1 antibody | |
| SH2 domain-containing inositol-5"-phosphatase 1 antibody | |
| SHIP-1 antibody | |
| SHIP1 antibody | |
| SHIP1_HUMAN antibody | |
| Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody | |
| SIP-145 antibody | |
| SIP145 antibody |
Target information
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression.
Provider
Erpantech Laboratory
