Anti-Phospho-Rac1+Cdc42 (S71) antibody
Specifications
| Product Cat#: | AB-06-3540 |
| Product type: | Primary antibody |
| Antigen: | Phospho-Rac1+Cdc42(Ser71) |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Ser71 of human CDC42. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry (1:40-1:200); Immunocytochemistry (1:40-1:200); Immunofluorescence |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JJ086-9) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA; 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CDC42Hs antibody |
| Cell division cycle 42 antibody | |
| G25K antibody | |
| MIG5 antibody | |
| Migration inducing gene 5 antibody | |
| P21 Rac1 antibody | |
| Ras like protein TC25 antibody | |
| Small GTP binding protein Cdc42 antibody | |
| TC25 antibody |
Target information
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase . Regulates cell migration . In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections . Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
Provider
Erpantech Laboratory
