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Anti-Phospho-P53 (T55) antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-3525
Anti-Phospho-P53 (T55) antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-3525
Product type: Primary antibody
Antigen: Phospho-P53 (T55)
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Thr55 of human p53.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:900)
Reactivity: Human
Clonality (clone number): Monoclonal (ST0439)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 0.05% BSA; 40% glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Antigen NY-CO-13 antibody
BCC7 antibody
Cellular tumor antigen p53 antibody
FLJ92943 antibody
LFS1 antibody
Mutant tumor protein 53 antibody
P53 antibody
P53 tumor suppressor antibody
P53_HUMAN antibody
Phosphoprotein p53 antibody
Tp53 antibody
Transformation related protein 53 antibody
TRP53 antibody
Tumor protein 53 antibody
Tumor protein p53 antibody
Tumor suppressor p53 antibody

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Target information

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.

Provider

Erpantech Laboratory

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MSDS-AB-06-3525.pdf (148 downloads )