Anti-Phospho-MLKL (S345) antibody
Specifications
| Product Cat#: | AB-06-3518 |
| Product type: | Primary antibody |
| Antigen: | MLKL (phospho S345) |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry(1:40-1:100) |
| Reactivity: | Mouse |
| Clonality (clone number): | Monoclonal (JM92-37) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA; 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 9130019I15Rik antibody |
| FLJ34389 antibody | |
| HhMLKL antibody | |
| Mixed lineage kinase domain like antibody | |
| Mixed lineage kinase domain like protein antibody | |
| Mixed lineage kinase domain like pseudokinase antibody | |
| Mixed lineage kinase domain-like protein antibody | |
| Mlkl antibody | |
| MLKL_HUMAN antibody |
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Target information
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity . Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (By similarity).
Miscellaneous
In contrast to human protein, not inhibited by necrosulfonamide, because a Trp residue is present instead of a Cys in position 85.
Interaction with RIPK3 is species specific: mouse MLKL only interacts with mouse RIPK3 and not human RIPK3.
Provider
Erpantech Laboratory