Anti-PHD2 antibody
Specifications
| Product Cat#: | AB-06-3453 |
| Product type: | Primary antibody |
| Antigen: | PHD2 |
| Immunogen: | Peptide |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot(1:900); Flow Cytometry(1:10-1:80); Immunocytochemistry(1:40-1:200); Immunohistochemistry (1:40-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA;40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C1ORF12 antibody |
| Chromosome 1 Open Reading Frame 12 antibody | |
| DKFZp761F179 antibody | |
| ECYT 3 antibody | |
| ECYT3 antibody | |
| EGL 9 homolog of C. elegans 1 antibody | |
| EGL nine (C.elegans) homolog 1 antibody | |
| Egl nine homolog 1 (C. elegans) antibody | |
| Egl nine homolog 1 antibody | |
| Egl nine like protein 1 antibody | |
| EGLN 1 antibody | |
| Egln1 antibody | |
| EGLN1_HUMAN antibody | |
| HIF PH2 antibody | |
| HIF Prolyl Hydroxylase 2 antibody | |
| HIF-PH2 antibody | |
| HIF-prolyl hydroxylase 2 antibody | |
| HIFP4 H 2 antibody | |
| HIFPH2 antibody | |
| HPH 2 antibody | |
| HPH-2 antibody | |
| HPH2 antibody | |
| Hypoxia inducible factor prolyl hydroxylase 2 antibody | |
| Hypoxia-inducible factor prolyl hydroxylase 2 antibody | |
| ORF13 antibody | |
| P4H2 antibody | |
| PHD 2 antibody | |
| PhD2 antibody | |
| PNAS 118 antibody | |
| PNAS 137 antibody | |
| Prolyl Hydroxylase Domain Containing Protein 2 antibody | |
| Prolyl hydroxylase domain-containing protein 2 antibody | |
| Rat Homolog of SM20 antibody | |
| SM 20 antibody | |
| SM-20 antibody | |
| SM20 antibody | |
| Zinc finger MYND domain containing protein 6 antibody | |
| ZMYND6 antibody |
Target information
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
Provider
Erpantech Laboratory
