Anti-PERK antibody
Specifications
| Product Cat#: | AB-06-4928 |
| Product type: | Primary antibody |
| Antigen: | PERK |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human EIF2AK3. AA range: 947-996. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-2000); Immunohistochemistry-Paraffin (1:150-1:300); Immunofluorescence (1:100-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.5% BSA, 50% Glycerol, 0.02% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | EIF2AK3; Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3; PERK; PEK; Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3; PRKR-Like Endoplasmic Reticulum Kinase; Pancreatic EIF2-Alpha Kinase; EC 2.7.11.1; Truncated Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3; HsPEK; WRS |
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Target information
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Provider
Erpantech Laboratory
