Anti-PEN2 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | PEN2 |
| Immunogen: | Synthetic peptide corresponding to C-terminal human PEN2. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:2100); Immunocytochemistry (1:100-1:250); Immunohistochemistry (1:100-1:250); Flow Cytometry (1:100-1:150) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal(JE41-28) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Gamma secretase subunit PEN 2 antibody |
| Gamma Secretase Subunit PEN2 antibody | |
| Gamma-secretase subunit PEN-2 antibody | |
| Hematopoietic stem/progenitor cells protein MDS033 antibody | |
| MDS033 antibody | |
| MSTP064 antibody | |
| PEN 2 antibody | |
| PEN2_HUMAN antibody | |
| Presenilin Enhancer 2 antibody | |
| Presenilin enhancer 2 homolog antibody | |
| Presenilin enhancer protein 2 antibody | |
| PSEN2 antibody | |
| psenen antibody |
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Target information
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).
Provider
Erpantech Laboratory
