Anti-PDK1 (Phospho-Tyr9) antibody
Specifications
| Product Cat#: | AB-07-3453 |
| Product type: | Primary antibody |
| Antigen: | PDK1 |
| Immunogen: | A synthetic peptide derived from PDK1 around the phosphorylation site of tyrosine 9 (Q-L-YP-D-A). The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:40000); Immunohistochemistry (1:50-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 3-phosphoinositide dependent protein kinase-1; EC 2.7.11.1; hPDK1; Kinase PDK1; mPDK1; PDPK1; PKB kinase; Protein kinase B kinase |
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Target information
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Provider
Erpantech Laboratory
