Anti-PDI antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | PDI |
| Immunogen: | recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | WesternBlot(1:1100-1:2100); Flow Cytometry(1:100-1:150) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal(JF97-08) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Pancreas specific protein disulfide isomerase antibody |
| Pancreas-specific protein disulfide isomerase antibody | |
| Pancreatic protein disulfide isomerase antibody | |
| PDA2 antibody | |
| PDI antibody | |
| PDIA2 antibody | |
| PDIA2_HUMAN antibody | |
| PDIp antibody | |
| PDIR antibody | |
| Protein disulfide isomerase A2 antibody | |
| Protein disulfide isomerase antibody | |
| Protein disulfide isomerase associated 2 antibody | |
| Protein disulfide isomerase family A member 2 antibody | |
| Protein disulfide isomerase pancreatic antibody | |
| Protein disulfide-isomerase A2 antibody | |
| Rho GDP dissociation inhibitor gamma antibody |
Target information
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).
Provider
Erpantech Laboratory
