Anti-PDCD4 (Ab-457) antibody
Specifications
| Product Cat#: | AB-07-3446 |
| Product type: | Primary antibody |
| Antigen: | PDCD4 |
| Immunogen: | A synthetic peptide derived from human PDCD4 around the phosphorylation site of serine 457 (F-V-SP-E-G). The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:1000); Western Blot (1:500-1:2500); Immunofluorescence (1:100-1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Neoplastic transformation inhibitor; Nuclear antigen H731-like; Programmed cell death protein 4 |
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Target information
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
Provider
Erpantech Laboratory
