Anti-PCAF antibody
Specifications
| Product Cat#: | AB-06-3374 |
| Product type: | Primary antibody |
| Antigen: | PCAF |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunoprecipitation (1:10-1:40); Flow Cytometry (1:40-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JU88-63) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CAF antibody |
| CREBBP associated factor antibody | |
| GCN5 antibody | |
| GCN5L antibody | |
| GCN5L1 antibody | |
| Histone acetylase PCAF antibody | |
| Histone acetyltransferase KAT2B antibody | |
| Histone acetyltransferase PCAF antibody | |
| K(lysine) acetyltransferase 2B antibody | |
| KAT2B antibody | |
| KAT2B_HUMAN antibody | |
| Lysine acetyltransferase 2B antibody | |
| P antibody | |
| P/CAF antibody | |
| p300/CBP associated factor antibody | |
| P300/CBP-associated factor antibody | |
| Pcaf antibody |
Target information
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acetylates spermidine (PubMed:27389534).
Provider
Erpantech Laboratory
