Anti-PBX1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | PBX1 |
| Immunogen: | KLH conjugated synthetic peptide derived from Human PBX1 221-340/430 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | 50ug;100ug;250ug (1:600-2100) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Zebrafish |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DKFZp686B09108 |
| Homeo box protein PBX1 | |
| Homeo box protein PRL | |
| Homeobox protein PBX 1 | |
| Homeobox protein PBX1 | |
| Homeobox protein PRL | |
| MGC126627 | |
| PBX 1 | |
| Pbx1 | |
| PBX1_HUMAN | |
| Pre B cell leukemia homeobox 1 | |
| Pre B cell leukemia transcription factor 1 | |
| Pre-B-cell leukemia transcription factor 1 |
Target information
Binds the sequence 5′-ATCAATCAA-3′. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).
Provider
Erpantech Laboratory
