Anti-PARP2 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | PARP2 |
| Immunogen: | Recombinant protein within the C-terminus of human PARP2. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:1100); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal(JG34-56) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ADP ribosyltransferase like 2 antibody |
| ADP-ribosyltransferase diphtheria toxin-like 2 antibody | |
| ADPRT 2 antibody | |
| ADPRT-2 antibody | |
| ADPRT2 antibody | |
| ADPRTL 2 antibody | |
| ADPRTL 3 antibody | |
| ADPRTL2 antibody | |
| ADPRTL3 antibody | |
| ARTD2 antibody | |
| hPARP 2 antibody | |
| hPARP-2 antibody | |
| hPARP2 antibody | |
| NAD(+) ADP ribosyltransferase 2 antibody | |
| NAD(+) ADP-ribosyltransferase 2 antibody | |
| pADPRT 2 antibody | |
| pADPRT-2 antibody | |
| pADPRT2 antibody | |
| PARP 2 antibody | |
| PARP-2 antibody | |
| PARP2 antibody | |
| PARP2_HUMAN antibody | |
| Poly (ADP ribose) polymerase family member 2 antibody | |
| Poly (ADP ribosyl) transferase like 2 antibody | |
| poly (ADP-ribose) polymerase 2 antibody | |
| Poly [ADP ribose] synthetase 2 antibody | |
| Poly [ADP-ribose] polymerase 2 antibody | |
| Poly(ADP ribose) synthetase antibody | |
| Poly[ADP-ribose] synthase 2 antibody |
Target information
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:28190768, PubMed:25043379). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD+ is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2′-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5′-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034).
Provider
Erpantech Laboratory
