Anti-PALB2 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | PALB2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human PALB2 1101-1186/1186 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-2200); Flow Cytometry(1μg/Test) |
| Reactivity: | Human, Mouse, Rat, Pig, Cow |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DKFZp667I166 |
| 4732427B05 | |
| BC066140 | |
| DKFZp686E1054 | |
| FANCN | |
| FANCN GENE | |
| FLJ21816 | |
| OTTMUSP00000025884 | |
| PALB2 | |
| partner and localizer of BRCA2 | |
| RGD1304759 |
Target information
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656).
Provider
Erpantech Laboratory
