Anti-PA26 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | PA26 |
| Immunogen: | KLH conjugated synthetic peptide derived from human SESN1/PA26 401-492/492 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | WesternBlot(1:600-1:2100); FlowCytometry(3ug/Test) |
| Reactivity: | Human, Mouse, Rat, Dog, Cow, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | p53 regulated PA26 nuclear protein |
| p53 regulated protein PA26 | |
| p53-regulated protein PA26 | |
| PA26 | |
| sesn1 | |
| SESN1_HUMAN | |
| SEST1 | |
| sestrin 1 |
Target information
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).
Provider
Erpantech Laboratory
