Anti-p53 DINP1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | p53 DINP1 |
| Immunogen: | Full length recombinant protein of human p53DINP1. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | WesternBlot(1:600-1:1100); Immunocytochemistry(1:100-1:300); Immunofluorescence; Immunohistochemistry (1:100-1:300) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal(JG37-64) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DKFZp434M1317 antibody |
| FLJ22139 antibody | |
| p53 damage inducible nuclear protein 1 antibody | |
| p53 dependent damage inducible nuclear protein 1 antibody | |
| p53 inducible nuclear protein 1 antibody | |
| p53 inducible p53DINP1 antibody | |
| p53-dependent damage-inducible nuclear protein 1 antibody | |
| p53DINP1 antibody | |
| SIP antibody | |
| Stress induced protein antibody | |
| Stress-induced protein antibody | |
| T53I1_HUMAN antibody | |
| Teap antibody | |
| TP53 DINP1 antibody | |
| TP53 INP1 antibody | |
| TP53DINP1 antibody | |
| TP53INP1 antibody | |
| TP53INP1A antibody | |
| TP53INP1B antibody | |
| Tumor protein p53 inducible nuclear protein 1 antibody | |
| Tumor protein p53-inducible nuclear protein 1 antibody |
Target information
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on ‘Ser-46’ and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Provider
Erpantech Laboratory
