Anti-OTUD4 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | OTUD4 |
| Immunogen: | Purified recombinant fragment of human OTUD4 expressed in E. Coli |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Rat |
| Clonality (clone number): | Monoclonal (G11-B12) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DKFZp434I0721 antibody |
| DUBA6 antibody | |
| HIN1 antibody | |
| HIV 1 induced protein HIN 1 antibody | |
| HIV 1 INTEGRATION 1 antibody | |
| HIV-1-induced protein HIN-1 antibody | |
| HSHIN antibody | |
| HSHIN1 antibody | |
| KIAA1046 antibody | |
| OTU domain containing 4 antibody | |
| OTU domain containing 4 protein antibody | |
| OTU domain-containing protein 4 antibody | |
| OTUD4 antibody | |
| OTUD4_HUMAN antibody |
Target information
Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates ‘Lys-63’-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111).
Provider
Erpantech Laboratory
