Anti-OPA1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | OPA1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1000); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:50-1:100); Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JM81-35) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Dynamin like 120 kDa protein antibody |
| Dynamin like 120 kDa protein, mitochondrial antibody | |
| Dynamin-like 120 kDa protein, form S1 antibody | |
| FLJ12460 antibody | |
| Juvenile kjer type optic atrophy antibody | |
| KIAA0567 antibody | |
| KJER type antibody | |
| Large GTP binding protein antibody | |
| largeG antibody | |
| MGM1 antibody | |
| Mitochondrial dynamin like 120 kDa protein antibody | |
| Mitochondrial dynamin like GTPase antibody | |
| NPG antibody | |
| NTG antibody | |
| OAK antibody | |
| OPA 1 antibody | |
| opa1 antibody | |
| OPA1 gene antibody | |
| OPA1_HUMAN antibody | |
| Optic atrophy 1 (autosomal dominant) antibody | |
| OPTIC ATROPHY 1 antibody | |
| Optic atrophy 1 gene protein antibody | |
| Optic atrophy 1 homolog (human) antibody | |
| Optic atrophy protein 1 antibody | |
| Optic atrophy protein 1 homolog antibody |
Target information
Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317).
Provider
Erpantech Laboratory