Anti-NOX2/gp91phox antibody
Specifications
| Product Cat#: | AB-06-3177 |
| Product type: | Primary antibody |
| Antigen: | NOX2/gp91phox |
| Immunogen: | Synthetic peptide corresponding to C-terminal human NOX2/gp91phox. |
| Species immunized: | Rabbit |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Immunocytochemistry (1:100-1:200); Immunohistochemistry(1:500-1:1000); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.5% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AMCBX2 antibody |
| CGD antibody | |
| CGD91-phox antibody | |
| CY24B_HUMAN antibody | |
| CYBB antibody | |
| Cytochrome b 245, beta polypeptide antibody | |
| Cytochrome b(558) beta chain antibody | |
| Cytochrome b(558) subunit beta antibody | |
| Cytochrome b-245 heavy chain antibody | |
| Cytochrome b558 subunit beta antibody | |
| GP91 PHOX antibody | |
| Gp91-1 antibody | |
| Gp91-phox antibody | |
| GP91PHOX antibody | |
| Heme-binding membrane glycoprotein gp91phox antibody | |
| NADPH oxidase 2 antibody | |
| Neutrophil cytochrome b 91 kDa polypeptide antibody | |
| NOX2 antibody | |
| P22 phagocyte B-cytochrome antibody | |
| P91 PHOX antibody | |
| P91-PHOX antibody | |
| Superoxide-generating NADPH oxidase heavy chain subunit antibody |
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Target information
Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet they have distinct expression patterns. gp91-phox is expressed in eosinophils, neutro-phils, monocytes and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, and low expression is also detected in the uterus and prostate. Mox1 is also upregulated in vascular smooth-muscle cells in response to PDGF stimulation, which collectively indicates that Mox1 may function analogously to gp91-phox, yet regulate the NADPH superoxide production in non-phagocytic cells.
Provider
Erpantech Laboratory