Anti-NOLC1 antibody
Specifications
| Product Cat#: | AB-07-3352 |
| Product type: | Primary antibody |
| Antigen: | NOLC1 |
| Immunogen: | A synthetic peptide derived from C-terminal of human NOLC1. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | ELISA (1:40000); Western Blot (1:500-1:2500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 140 kDa nucleolar phosphoprotein; HCV NS5Atrans-regulated protein 13; HCV NS5A-transactivated protein 13; Hepatitis C virus NS5A-transactivated protein 13; KIAA0035; NOLC1; NOPP130; Nopp140; NS5ATP13; Nucleolar 130 kDa protein; Nucleolar and coiled-body phosphoprotein 1; Nucleolar and |
| coiled-body phosphprotein 1; Nucleolar phosphoprotein p130; Nucleolar protein p130; P130 |
Target information
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).
Provider
Erpantech Laboratory
