Anti-Nocturnin antibody
Specifications
| Product Cat#: | AB-06-31667 |
| Product type: | Primary antibody |
| Antigen: | Nocturnin |
| Immunogen: | KLH conjugated synthetic peptide derived from human Nocturnin 231-330/431 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000); Immunohistochemistry-Paraffin (1:500-800) |
| Reactivity: | Human, Mouse, Rat, Chicken, Pig, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CCR4 carbon catabolite repression 4 like (S. cerevisiae) |
| CCR4 protein homolog | |
| CCRN4L | |
| NOC | |
| NOCT_HUMAN. |
Target information
Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control. May have low deadenylase activity and may degrade the poly(A) tails of specific target mRNAs, leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).
Provider
Erpantech Laboratory
