Anti-Nmnat1 antibody
Specifications
| Product Cat#: | AB-06-3162 |
| Product type: | Primary antibody |
| Antigen: | Nmnat1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Nmnat1 201-279/279 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | NaMN adenylyltransferase 1 |
| Nicotinamide mononucleotide adenylyltransferase 1 | |
| Nicotinamide nucleotide adenylyltransferase 1 | |
| Nicotinate nucleotide adenylyltransferase 1 | |
| Nicotinate-nucleotide adenylyltransferase 1 | |
| NMN adenylyltransferase 1 | |
| NMNA1_HUMAN | |
| Nmnat 1 | |
| Nmnat1 | |
| Nmnat-1 | |
| OTTHUMP00000001731 | |
| OTTHUMP00000001732 | |
| OTTHUMP00000035892 | |
| PNAT 1 | |
| PNAT1 |
Target information
Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency . Can use triazofurin monophosphate (TrMP) as substrate . Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+ . For the pyrophosphorolytic activity, prefers NAD+ and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively . Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming . Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+ Protects against axonal degeneration following mechanical or toxic insults (By similarity).
Provider
Erpantech Laboratory
