Anti-NMDAR2B antibody
Specifications
| Product Cat#: | AB-06-3158 |
| Product type: | Primary antibody |
| Antigen: | NMDAR2B |
| Immunogen: | Rabbit polyclonal Antibody |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000); Immunohistochemistry-Paraffin (1:500-800); Immunocytochemistry (1:100-1:400)/Immunofluorescence(1:100-1:400) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | NMDA2B (epsilon 2) |
| GRIN 2B | |
| GRIN2B | |
| HNR 3 | |
| HNR3 | |
| MGC142178 | |
| MGC142180 | |
| N methyl D asparate receptor channel subunit epsilon 2 | |
| N METHYL D ASPARTATE RECEPTOR CHANNEL SUBUNIT EPSILON 2 | |
| N methyl D aspartate receptor subunit 2B | |
| N methyl D aspartate receptor subunit 3 | |
| NMDA NR2B | |
| NMDA R2B | |
| Nmdar2b | |
| NMDE2 | |
| NME2 | |
| NR2B | |
| NR3 | |
| N-Methyl-d-Asprtate receptor 2B | |
| AW490526 | |
| Glutamate [NMDA] receptor subunit epsilon 2 | |
| Glutamate Receptor Ionotropic N Methyl D Aspartate 2B | |
| Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B | |
| Glutamate receptor ionotropic NMDA2B | |
| Glutamate receptor subunit epsilon 2 | |
| Glutamate receptor, ionotropic | |
| NMDE2_HUMAN |
Target information
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ . Sensitivity to glutamate and channel kinetics depend on the subunit composition. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
Provider
Erpantech Laboratory
