Anti-NLRP9 antibody
Specifications
| Product Cat#: | AB-06-3152 |
| Product type: | Primary antibody |
| Antigen: | NLRP9 |
| Immunogen: | KLH conjugated synthetic peptide derived from human NLRP9 701-800/991 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | LRR and PYD domains-containing protein 9 |
| NACHT | |
| NACHT, LRR and PYD domains-containing protein 9 | |
| NALP9_HUMAN | |
| NLRP9 | |
| Nucleotide-binding oligomerization domain protein 6 |
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Target information
As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.
Provider
Erpantech Laboratory
