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Anti-NLRP3 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-3150
Anti-NLRP3 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-3150
Product type: Primary antibody
Antigen: NLRP3
Immunogen: Peptide
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:200-1:2000); Immunocytochemistry (1:500-1:2000); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:50-1:200)
Reactivity: Mouse and Human
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.5% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Antigen affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
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Target information

As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K+ efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33 (PubMed:23871209). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5′-GRRGGNRGAG-3′. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity).

Provider

Erpantech Laboratory

download

MSDS-AB-06-3150.pdf (109 downloads )