No products in the cart.

Anti-NLRC3 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-3147
Anti-NLRC3 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-3147
Product type: Primary antibody
Antigen: NLRC3
Immunogen: Peptide
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:200-1:2000); Immunocytochemistry (1:100-1:200); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:100-1:200)
Reactivity: Mouse and Human
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.5% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Antigen affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: CARD15-like antibody
CARD15-like protein antibody
Caterpiller 16.2 antibody
Caterpiller protein 16.2 antibody
CLR16.2 antibody
FLJ00348 antibody
NLR family CARD domain containing 3 antibody
Nlrc3 antibody
NLRC3_HUMAN antibody
NOD-like receptor C3 antibody
NOD3 antibody
NOD3 protein antibody
Nucleotide-binding oligomerization domain protein 3 antibody
Nucleotide-binding oligomerization domain protein 3 caterpiller 16.2 antibody
nucleotide-binding oligomerization domain, leucine rich repeat and CARD
Show More

Target information

Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (PubMed:22863753, PubMed:24560620). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating ‘Lys-63’-linked ubiquitination and leaving unchanged the degradative ‘Lys-48’-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (PubMed:27951586). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (By similarity). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (By similarity).

Provider

Erpantech Laboratory

download

MSDS-AB-06-3147.pdf (121 downloads )