Anti-NKG2D antibody
Specifications
| Product Cat#: | AB-06-3143 |
| Product type: | Primary antibody |
| Antigen: | NKG2D |
| Immunogen: | KLH conjugated synthetic peptide derived from human NKG2D 121-219/219 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000); Flow Cytometry: 1μg/Test |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | KLRK1 |
| natural killer cell group 2D | |
| NKG2-D isoform b | |
| Klrk1 | |
| Nkrp2 | |
| NKG2-D type II integral membrane protein | |
| NKG2-D-activating NK receptor | |
| NK cell receptor D | |
| Killer cell lectin-like receptor subfamily K | |
| NK lectin-like receptor | |
| CD314 | |
| CD 314 | |
| CD314 antigen | |
| D12S2489E | |
| Killer cell lectin like receptor subfamily K member 1 | |
| Killer cell lectin-like receptor subfamily K member 1 | |
| KLR | |
| Klrk1 | |
| NKG2 D activating NK receptor | |
| NKG2 D type II integral membrane protein | |
| NKG2-D-activating NK receptor | |
| NKG2D_HUMAN | |
| NKLLR | |
| NKR P2 |
Target information
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1.
Provider
Erpantech Laboratory
