Anti-Niemann Pick C1 antibody (KO Validated)
Specifications
| Product Cat#: | AB-06-3139 |
| Product type: | Primary antibody |
| Antigen: | Niemann Pick C1 |
| Immunogen: | Recombinant protein within Human Niemann Pick C1 aa 1,160-1,278/1,278. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:1000); Immunocytochemistry/Immunofluorescence (1:100-1:200); Immunohistochemistry-Paraffin (1:100-1:200); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JB87-33) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Niemann Pick C1 protein precursor antibody |
| Niemann Pick disease, type C1 antibody | |
| Niemann-Pick C1 protein antibody | |
| NPC antibody | |
| NPC1 antibody | |
| NPC1_HUMAN antibody |
Target information
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed:9927649, PubMed:10821832, PubMed:18772377, PubMed:27238017, PubMed:12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:9211849, PubMed:9927649, PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
Provider
Erpantech Laboratory
