Anti-Nicastrin antibody
Specifications
| Product Cat#: | AB-06-3138 |
| Product type: | Primary antibody |
| Antigen: | Nicastrin |
| Immunogen: | Synthetic peptide within Human Nicastrin aa 650-750 (C terminal). |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal(JG68-33) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Anterior pharynx defective 2 antibody |
| APH 2 antibody | |
| APH2 antibody | |
| ATAG1874 antibody | |
| KIAA0253 antibody | |
| Ncstn antibody | |
| NCT antibody | |
| NICA_HUMAN antibody | |
| Nicastrin antibody | |
| RP11 517F10.1 antibody | |
| RP11517F101 antibody |
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Target information
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Provider
Erpantech Laboratory
