Anti-NGF Recepr antibody
Specifications
| Product Cat#: | AB-06-3135 |
| Product type: | Primary antibody |
| Antigen: | NGF Recepr |
| Immunogen: | Amino acids 393-427 at the C-terminus of NGFR p75 of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:1000); Immunoprecipitation(1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) ); Immunofluorescence(1:50-1:500) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal(2G2) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CD271 antibody |
| CD271 antigen antibody | |
| Gp80 LNGFR antibody | |
| Gp80-LNGFR antibody | |
| Low affinity nerve growth factor receptor antibody | |
| Low affinity neurotrophin receptor p75NTR antibody | |
| Low-affinity nerve growth factor receptor antibody | |
| Nerve growth factor receptor antibody | |
| Nerve growth factor receptor TNFR superfamily member 16 antibody | |
| NGF receptor antibody | |
| Ngfr antibody | |
| p75 ICD antibody |
Target information
The Trk oncogene encodes a membrane-spanning protein tyrosine kinase, gp140Trk, whose expression is restricted in vivo to neurons of the sensory spinal and cranial ganglia of neural crest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Tyrosine phosphorylation of Trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF, suggesting that Trk A participates in the primary signal transduction mechanism of NGF. An additional component of the Trk A receptor complex, NGFR p75, binds to the neurotrophic factors with low affinity but is required for efficient signaling. NGFR p75 accelerates Trk A activation and may recruit downstream effector molecules to the liganded complex.
Provider
Erpantech Laboratory
