Anti-NEDD4-2 Recombinant Rabbit Monoclonal antibody
Specifications
| Product Cat#: | AB-06-3076 | |
| Product type: | Primary antibody | |
| Antigen: | NEDD4-2 | |
| Immunogen: | Synthetic peptide within Human NEDD4-2 aa 926-975 / 975. | |
| Species immunized: | Rabbit | |
| Isotype: | IgG | |
| Applications: | Western Blot ( 1:500-1:5000 ); Immunoprecipitation | |
| Reactivity: | Mouse, Rat and Human | |
| Clonality (clone number): | Polyclonal | |
| Form: | Liquid | |
| Buffer: | 1*TBS ( pH7.4 ), 0.05% BSA, 40 %Glycerol, 0.05 % Sodium Azide. | |
| Concentration: | 1 mg/ml | |
| Purity: | Protein A affinity purified | |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. | |
| Alternative names: | E3 Ubiquitin Protein Ligase NEDD4 like Protein Antibody | |
| E3 Ubiquitin-protein Ligase NEDD4-like Antibody | ||
| KIAA0439 Antibody | ||
| NED4L_HUMAN Antibody | ||
| NEDD4 2 Antibody | ||
| NEDD4 2c Antibody | ||
| Nedd4-2 Antibody | ||
| NEDD4-2a Antibody | ||
| NEDD4.2 Antibody | ||
| NEDD4b Antibody | ||
| NEDD4L Antibody | ||
| NEDD4La Antibody | ||
| NEDD4Lb Antibody | ||
| NEDD4Lc Antibod | y |
Target information
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338).
Provider
Erpantech Laboratory
