Anti-N-Cadherin antibody
Specifications
| Product Cat#: | AB-06-3058 |
| Product type: | Primary antibody |
| Antigen: | N-Cadherin |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:400-1:1500 );Immunocytochemistry ( 1:50-1:200 ); Immunofluorescence ( 1:50 );Immunohistochemistry ( 1:100-1:150 ) |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS ( pH7.4 ), 1 %BSA, 40 %Glycerol. Preservative: 0.05 % Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CADH2_HUMAN Antibody |
| Cadherin 2 Antibody | |
| Cadherin 2 N Cadherin Neuronal Antibody | |
| Cadherin 2 Type 1 Antibody | |
| Cadherin 2 type 1 N Cadherin Neuronal Antibody |
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Target information
The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway, which phosphorylates beta-catenins attached to both N-cadherin (this protein) and E-cadherins.
Provider
Erpantech Laboratory
